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CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

  • Author(s): Perry, Arie
  • Spence, T
  • Sin-Chan, P
  • Picard, D
  • Barszczyk, M
  • Hoss, K
  • Lu, M
  • Kim, S-K
  • Ra, Y-S
  • Nakamura, H
  • Fangusaro, J
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4159569?pdf=render
No data is associated with this publication.
Abstract

Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specifici

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