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Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones.

  • Author(s): Roth, Aaron;
  • Ott, Sean;
  • Farber, Kelli M;
  • Palazzo, Teresa A;
  • Conrad, Wayne E;
  • Haddadin, Makhluf J;
  • Tantillo, Dean J;
  • Cross, Carroll E;
  • Eiserich, Jason P;
  • Kurth, Mark J
  • et al.
Abstract

Myeloperoxidase (MPO) produces hypohalous acids as a key component of the innate immune response; however, release of these acids extracellularly results in inflammatory cell and tissue damage. The two-step, one-pot Davis-Beirut reaction was used to synthesize a library of 2H-indazoles and 1H-indazolones as putative inhibitors of MPO. A structure-activity relationship study was undertaken wherein compounds were evaluated utilizing taurine-chloramine and MPO-mediated H2O2 consumption assays. Docking studies as well as toxicophore and Lipinski analyses were performed. Fourteen compounds were found to be potent inhibitors with IC50 values <1μM, suggesting these compounds could be considered as potential modulators of pro-oxidative tissue injury pertubated by the inflammatory MPO/H2O2/HOCl/HOBr system.

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