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Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation
Published Web Location
http://europepmc.org/articles/PMC3781465?pdf=renderNo data is associated with this publication.
Abstract
Sirt3 is an NAD+-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion o
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