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Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation

  • Author(s): Verdin, Eric
  • Jing, E
  • O'Neill, BT
  • Rardin, MJ
  • Kleinridders, A
  • Ilkeyeva, OR
  • Ussar, S
  • Bain, JR
  • Lee, KY
  • Verdin, EM
  • Newgard, CB
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3781465?pdf=render
No data is associated with this publication.
Abstract

Sirt3 is an NAD+-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion o

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