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Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing

  • Author(s): Guthrie, Christine
  • Krishnan, R
  • Blanco, MR
  • Kahlscheuer, ML
  • Abelson, J
  • Walter, NG
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3867266?pdf=render
No data is associated with this publication.
Abstract

The spliceosome is a dynamic ribonucleoprotein (RNP) machine that catalyzes the removal of introns during the two transesterification steps of eukaryotic pre-mRNA splicing. Here we used single-molecule fluorescence resonance energy transfer to monitor the

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