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Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing
Published Web Location
http://europepmc.org/articles/PMC3867266?pdf=renderNo data is associated with this publication.
Abstract
The spliceosome is a dynamic ribonucleoprotein (RNP) machine that catalyzes the removal of introns during the two transesterification steps of eukaryotic pre-mRNA splicing. Here we used single-molecule fluorescence resonance energy transfer to monitor the
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