Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing
- Author(s): Guthrie, Christine
- Krishnan, R
- Blanco, MR
- Kahlscheuer, ML
- Abelson, J
- Walter, NG
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3867266?pdf=render
The spliceosome is a dynamic ribonucleoprotein (RNP) machine that catalyzes the removal of introns during the two transesterification steps of eukaryotic pre-mRNA splicing. Here we used single-molecule fluorescence resonance energy transfer to monitor the
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