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A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease.

  • Author(s): Caussy, Cyrielle
  • Tripathi, Anupriya
  • Humphrey, Greg
  • Bassirian, Shirin
  • Singh, Seema
  • Faulkner, Claire
  • Bettencourt, Ricki
  • Rizo, Emily
  • Richards, Lisa
  • Xu, Zhenjiang Z
  • Downes, Michael R
  • Evans, Ronald M
  • Brenner, David A
  • Sirlin, Claude B
  • Knight, Rob
  • Loomba, Rohit
  • et al.

Published Web Location

https://www.nature.com/articles/s41467-019-09455-9
No data is associated with this publication.
Abstract

The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions of 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing the entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-resonance-imaging. We show strong familial correlation of gut-microbiome profiles, driven by shared housing. We report a panel of 30 features, including 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using a Random Forest classifier model. In a derivation cohort of probands, the model has a robust diagnostic accuracy (AUROC of 0.92) for detecting NAFLD-cirrhosis, confirmed in a validation cohort of relatives of proband with NAFLD-cirrhosis (AUROC of 0.87). This study provides evidence for a fecal-microbiome-derived signature to detect NAFLD-cirrhosis.

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