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A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.
- Author(s): Hellmuth, Joanna
- Milanini, Benedetta
- Masliah, Eliezer
- Tartaglia, Maria Carmela
- Dunlop, Miranda B
- Moore, David J
- Javandel, Shireen
- DeVaughn, Saskia
- Valcour, Victor
- et al.
Published Web Locationhttps://www.tandfonline.com/doi/full/10.1080/13554794.2018.1530362
We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.
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