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Open Access Publications from the University of California

A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.

  • Author(s): Hellmuth, Joanna;
  • Milanini, Benedetta;
  • Masliah, Eliezer;
  • Tartaglia, Maria Carmela;
  • Dunlop, Miranda B;
  • Moore, David J;
  • Javandel, Shireen;
  • DeVaughn, Saskia;
  • Valcour, Victor
  • et al.

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We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.

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