Epidermodysplasia verruciformis: report of two patients with autosomal dominant inheritance
- Author(s): Miotto, Isadora Zago;
- de Oliveira, Walmar Roncalli Pereira
- et al.
Published Web Locationhttps://doi.org/10.5070/D3272052388
Epidermodysplasia verruciformis is a rare genodermatosis associated with mutations in the EVER1/TMC6 and EVER2/TMC8 genes. The inheritance is considered to be autosomal recessive, but reports suggesting an autosomal dominant inheritance indicate disease genetic heterogeneity. Its onset occurs in early childhood and presents as a combination of pityriasis versicolor-like, flat wart-like and seborrheic keratosis-like lesions, with a potential for malignant transformation, mainly squamous cell carcinoma.