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Epidermodysplasia verruciformis: report of two patients with autosomal dominant inheritance

  • Author(s): Miotto, Isadora Zago
  • de Oliveira, Walmar Roncalli Pereira
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

Epidermodysplasia verruciformis is a rare genodermatosis associated with mutations in the EVER1/TMC6 and EVER2/TMC8 genes. The inheritance is considered to be autosomal recessive, but reports suggesting an autosomal dominant inheritance indicate disease genetic heterogeneity. Its onset occurs in early childhood and presents as a combination of pityriasis versicolor-like, flat wart-like and seborrheic keratosis-like lesions, with a potential for malignant transformation, mainly squamous cell carcinoma.

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