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T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

  • Author(s): Meller, Stephan
  • Di Domizio, Jeremy
  • Voo, Kui S
  • Friedrich, Heike C
  • Chamilos, Georgios
  • Ganguly, Dipyaman
  • Conrad, Curdin
  • Gregorio, Josh
  • Le Roy, Didier
  • Roger, Thierry
  • Ladbury, John E
  • Homey, Bernhard
  • Watowich, Stanley
  • Modlin, Robert L
  • Kontoyiannis, Dimitrios P
  • Liu, Yong-Jun
  • Arold, Stefan T
  • Gilliet, Michel
  • et al.

Published Web Location

http://www.ncbi.nlm.nih.gov/pubmed/26168081
No data is associated with this publication.
Abstract

Interleukin 17-producing helper T cells (T(H)17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, T(H)17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of T(H)17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death.

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