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Composite liver tumors: a radiologic-pathologic correlation.

  • Author(s): Nayyar, M
  • Imagawa, DK
  • Tirkes, T
  • Demirjian, AN
  • Houshyar, R
  • Sandrasegaran, K
  • Nangia, CS
  • Seery, T
  • Bhargava, P
  • Choi, JI
  • Lall, C
  • et al.
Abstract

Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.

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