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Composite liver tumors: a radiologic-pathologic correlation.
- Author(s): Nayyar, M
- Imagawa, DK
- Tirkes, T
- Demirjian, AN
- Houshyar, R
- Sandrasegaran, K
- Nangia, CS
- Seery, T
- Bhargava, P
- Choi, JI
- Lall, C
- et al.
Published Web Location
https://doi.org/10.3350/cmh.2014.20.4.406Abstract
Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.
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