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Open Access Publications from the University of California

Composite liver tumors: a radiologic-pathologic correlation.

  • Author(s): Nayyar, Megha
  • Imagawa, David K
  • Tirkes, Temel
  • Demirjian, Aram N
  • Houshyar, Roozbeh
  • Sandrasegaran, Kumar
  • Nangia, Chaitali S
  • Seery, Tara
  • Bhargava, P
  • Choi, Joon Ii
  • Lall, Chandana
  • et al.

Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.

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