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Composite liver tumors: a radiologic-pathologic correlation.
- Author(s): Nayyar, Megha
- Imagawa, David K
- Tirkes, Temel
- Demirjian, Aram N
- Houshyar, Roozbeh
- Sandrasegaran, Kumar
- Nangia, Chaitali S
- Seery, Tara
- Bhargava, P
- Choi, Joon Ii
- Lall, Chandana
- et al.
Published Web Location
https://doi.org/10.3350/cmh.2014.20.4.406Abstract
Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.
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