Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers in T cells
- Author(s): Roose, Jeroen
- Jun, JE
- Rubio, I
- Roose, JP
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3762125?pdf=render
The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating rec