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Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers in T cells

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http://europepmc.org/articles/PMC3762125?pdf=render
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Abstract

The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating rec

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