Skip to main content
eScholarship
Open Access Publications from the University of California

UCSF

UC San Francisco Previously Published Works bannerUCSF

Design of MARQUIS2: study protocol for a mentored implementation study of an evidence-based toolkit to improve patient safety through medication reconciliation.

  • Author(s): Mixon, Amanda S
  • Smith, G Randy
  • Mallouk, Meghan
  • Nieva, Harry Reyes
  • Kripalani, Sunil
  • Rennke, Stephanie
  • Chu, Eugene
  • Sridharan, Anirudh
  • Dalal, Anuj
  • Mueller, Stephanie
  • Williams, Mark
  • Wetterneck, Tosha
  • Stein, Jason M
  • Stolldorf, Deonni
  • Howell, Eric
  • Orav, John
  • Labonville, Stephanie
  • Levin, Brian
  • Yoon, Catherine
  • Gresham, Marcus
  • Goldstein, Jenna
  • Platt, Sara
  • Nyenpan, Christopher
  • Schnipper, Jeffrey L
  • MARQUIS2 Site Leaders
  • MARQUIS2 Study Group
  • et al.
Abstract

Background

The first Multi-center Medication Reconciliation Quality Improvement Study (MARQUIS1) demonstrated that implementation of a medication reconciliation best practices toolkit decreased total unintentional medication discrepancies in five hospitals. We sought to implement the MARQUIS toolkit in more diverse hospitals, incorporating lessons learned from MARQUIS1.

Methods

MARQUIS2 is a pragmatic, mentored implementation QI study which collected clinical and implementation outcomes. Sites implemented a revised toolkit, which included interventions from these domains: 1) best possible medication history (BPMH)-taking; 2) discharge medication reconciliation and patient/caregiver counseling; 3) identifying and defining clinician roles and responsibilities; 4) risk stratification; 5) health information technology improvements; 6) improved access to medication sources; 7) identification and correction of real-time discrepancies; and, 8) stakeholder engagement. Eight hospitalists mentored the sites via one site visit and monthly phone calls over the 18-month intervention period. Each site's local QI team assessed opportunities to improve, implemented at least one of the 17 toolkit components, and accessed a variety of resources (e.g. implementation manual, webinars, and workshops). Outcomes to be assessed will include unintentional medication discrepancies per patient.

Discussion

A mentored multi-center medication reconciliation QI initiative using a best practices toolkit was successfully implemented across 18 medical centers. The 18 participating sites varied in size, teaching status, location, and electronic health record (EHR) platform. We introduce barriers to implementation and lessons learned from MARQUIS1, such as the importance of utilizing dedicated, trained medication history takers, simple EHR solutions, clarifying roles and responsibilities, and the input of patients and families when improving medication reconciliation.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View