A delayed injection-site reaction in a patient receiving extended-release naltrexone.
- Author(s): Ahamad, Keith
- Korthuis, P Todd
- Lum, Paula J
- Johnson, Cheyenne
- Wood, Evan
- et al.
Published Web Locationhttps://doi.org/10.1080/08897077.2016.1138919
Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection.The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction.Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.