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Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.
- Rouphael, Nadine;
- Branche, Angela;
- Diemert, David;
- Falsey, Ann;
- Losada, Cecilia;
- Baden, Lindsey;
- Frey, Sharon;
- Whitaker, Jennifer;
- Little, Susan;
- Kamidani, Satoshi;
- Walter, Emmanuel;
- Novak, Richard;
- Rupp, Richard;
- Jackson, Lisa;
- Babu, Tara;
- Kottkamp, Angelica;
- Luetkemeyer, Anne;
- Immergluck, Lilly;
- Presti, Rachel;
- Bäcker, Martín;
- Winokur, Patricia;
- Mahgoub, Siham;
- Goepfert, Paul;
- Fusco, Dahlene;
- Atmar, Robert;
- Posavad, Christine;
- Netzl, Antonia;
- Smith, Derek;
- Telu, Kalyani;
- Mu, Jinjian;
- McQuarrie, Lisa;
- Makowski, Mat;
- Makhene, Mamodikoe;
- Crandon, Sonja;
- Montefiori, David;
- Roberts, Paul;
- Beigel, John
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiad323Abstract
We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.
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