Skip to main content
Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in β Cells.
Published Web Locationhttps://doi.org/10.1210/js.2016-1042
Aims/hypothesisWe sought to establish whether the increased incidence of diabetes associated with Down syndrome was due to a congenital deficit in β cells.
MethodsThe pancreas was obtained at autopsy from nondiabetic subjects with Down syndrome (n = 29) and age-matched nondiabetic control subjects without Down syndrome (n = 28). The pancreas sections were evaluated for the fractional β-cell area.
ResultsNo difference was found in the fractional β-cell area between the subjects with Down syndrome and the control subjects.
Conclusions/interpretationsThe increased incidence and prevalence of diabetes in individuals with Down syndrome is not due to an underlying congenital deficiency of β cells.
For improved accessibility of PDF content, download the file to your device.