Skip to main content
eScholarship
Open Access Publications from the University of California

UCLA

UCLA Previously Published Works bannerUCLA

Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in β Cells.

Abstract

Aims/hypothesis

We sought to establish whether the increased incidence of diabetes associated with Down syndrome was due to a congenital deficit in β cells.

Methods

The pancreas was obtained at autopsy from nondiabetic subjects with Down syndrome (n = 29) and age-matched nondiabetic control subjects without Down syndrome (n = 28). The pancreas sections were evaluated for the fractional β-cell area.

Results

No difference was found in the fractional β-cell area between the subjects with Down syndrome and the control subjects.

Conclusions/interpretations

The increased incidence and prevalence of diabetes in individuals with Down syndrome is not due to an underlying congenital deficiency of β cells.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View