Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in β Cells.
- Author(s): Butler, Alexandra E
- Sacks, Wendy
- Rizza, Robert A
- Butler, Peter C
- et al.
Published Web Locationhttps://doi.org/10.1210/js.2016-1042
We sought to establish whether the increased incidence of diabetes associated with Down syndrome was due to a congenital deficit in β cells.The pancreas was obtained at autopsy from nondiabetic subjects with Down syndrome (n = 29) and age-matched nondiabetic control subjects without Down syndrome (n = 28). The pancreas sections were evaluated for the fractional β-cell area.No difference was found in the fractional β-cell area between the subjects with Down syndrome and the control subjects.The increased incidence and prevalence of diabetes in individuals with Down syndrome is not due to an underlying congenital deficiency of β cells.