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Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos
- Zhang, Yuan;
- Elgart, Michael;
- Granot-Hershkovitz, Einat;
- Wang, Heming;
- Tarraf, Wassim;
- Ramos, Alberto R;
- Stickel, Ariana M;
- Zeng, Donglin;
- Garcia, Tanya P;
- Testai, Fernando D;
- Wassertheil-Smoller, Sylvia;
- Isasi, Carmen R;
- Daviglus, Martha L;
- Kaplan, Robert;
- Fornage, Myriam;
- DeCarli, Charles;
- Redline, Susan;
- González, Hector M;
- Sofer, Tamar
Published Web Location
https://doi.org/10.1016/j.ebiom.2022.104393Abstract
Background
Sleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polygenic Risk Scores (PRSs) for sleep duration, insomnia, daytime sleepiness, and obstructive sleep apnoea (OSA) and measures of cogntive ageing in Hispanic/Latino adults.Methods
We used summary statistics from published genome-wide association studies to construct PRSs representing the genetic basis of each sleep trait, then we studied the association of the PRSs of the sleep phenotypes with cognitive outcomes in the Hispanic Community Healthy Study/Study of Latinos. The primary model adjusted for age, sex, study centre, and measures of genetic ancestry. Associations are highlighted if their p-value <0.05.Findings
Higher PRS for insomnia was associated with lower global cognitive function and higher risk of mild cognitive impairment (MCI) (OR = 1.20, 95% CI [1.06, 1.36]). Higher PRS for daytime sleepiness was also associated with increased MCI risk (OR = 1.14, 95% CI [1.02, 1.28]). Sleep duration PRS was associated with reduced MCI risk among short and normal sleepers, while among long sleepers it was associated with reduced global cognitive function and with increased MCI risk (OR = 1.40, 95% CI [1.10, 1.78]). Furthermore, adjustment of analyses for the measured sleep phenotypes and APOE-ε4 allele had minor effects on the PRS associations with the cognitive outcomes.Interpretation
Genetic measures underlying insomnia, daytime sleepiness, and sleep duration are associated with MCI risk. Genetic and self-reported sleep duration interact in their effect on MCI.Funding
Described in Acknowledgments.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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