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Open Access Publications from the University of California

Reduction in Revascularization With Icosapent Ethyl: Insights From REDUCE-IT Revascularization Analyses.

  • Author(s): Peterson, Benjamin E
  • Bhatt, Deepak L
  • Steg, Ph Gabriel
  • Miller, Michael
  • Brinton, Eliot A
  • Jacobson, Terry A
  • Ketchum, Steven B
  • Juliano, Rebecca A
  • Jiao, Lixia
  • Doyle, Ralph T
  • Granowitz, Craig
  • Gibson, C Michael
  • Pinto, Duane
  • Giugliano, Robert P
  • Budoff, Matthew J
  • Tardif, Jean-Claude
  • Verma, Subodh
  • Ballantyne, Christie M
  • REDUCE-IT Investigators
  • et al.


Patients with elevated triglycerides despite statin therapy have increased risk for ischemic events, including coronary revascularizations.


REDUCE-IT (The Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial), a multicenter, double-blind, placebo-controlled trial, randomly assigned statin-treated patients with elevated triglycerides (135-499 mg/dL), controlled low-density lipoprotein (41-100 mg/dL), and either established cardiovascular disease or diabetes plus other risk factors to receive icosapent ethyl 4 g/d or placebo. The primary and key secondary composite end points were significantly reduced. Prespecified analyses examined all coronary revascularizations, recurrent revascularizations, and revascularization subtypes.


A total of 8179 randomly assigned patients were followed for 4.9 years (median). First revascularizations were reduced to 9.2% (22.5/1000 patient-years) with icosapent ethyl versus 13.3% (33.7/1000 patient-years) with placebo (hazard ratio, 0.66 [95% CI, 0.58-0.76]; P<0.0001; number needed to treat for 4.9 years=24); similar reductions were observed in total (first and subsequent) revascularizations (negative binomial rate ratio, 0.64 [95% CI, 0.56-0.74]; P<0.0001), and across elective, urgent, and emergent revascularizations. Icosapent ethyl significantly reduced percutaneous coronary intervention (hazard ratio, 0.68 [95% CI, 0.59-0.79]; P<0.0001) and coronary artery bypass grafting (hazard ratio, 0.61 [95% CI, 0.45-0.81]; P=0.0005).


Icosapent ethyl reduced the need for first and subsequent coronary revascularizations in statin-treated patients with elevated triglycerides and increased cardiovascular risk. To our knowledge, icosapent ethyl is the first non-low-density lipoprotein-lowering treatment that has been shown to reduce coronary artery bypass grafting in a blinded, randomized trial. Registration: URL:; Unique identifier: NCT01492361.

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