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Open Access Publications from the University of California

Topical vitamin-A-acid therapy for cutaneous metastatic melanoma.

  • Author(s): Levine, N
  • Meyskens, FL
  • et al.
Abstract

Two patients with cutaneous metastatic melanoma were treated with a topical retinoid, beta-all-trans-retinoic acid. Complete regression of the treated lesions was noted in one patient and a partial response was seen in the other patient. The mechanism of anti-tumour action of the retinoids is not completely known but binding to intracytoplasmic receptors with promotion of cellular differentiation, alteration of membranes, and immunological adjuvant effects may be involved.

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