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Open Access Publications from the University of California

Large-scale gene-expression studies and the challenge of multiple sclerosis.

  • Author(s): Baranzini, Sergio E
  • Hauser, Stephen L
  • et al.

In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.

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