Large-scale gene-expression studies and the challenge of multiple sclerosis.
- Author(s): Baranzini, Sergio E
- Hauser, Stephen L
- et al.
Published Web Locationhttps://doi.org/10.1186/gb-2002-3-10-reviews1027
In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.