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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
- Gaulton, Kyle J;
- Ferreira, Teresa;
- Lee, Yeji;
- Raimondo, Anne;
- Mägi, Reedik;
- Reschen, Michael E;
- Mahajan, Anubha;
- Locke, Adam;
- William Rayner, N;
- Robertson, Neil;
- Scott, Robert A;
- Prokopenko, Inga;
- Scott, Laura J;
- Green, Todd;
- Sparso, Thomas;
- Thuillier, Dorothee;
- Yengo, Loic;
- Grallert, Harald;
- Wahl, Simone;
- Frånberg, Mattias;
- Strawbridge, Rona J;
- Kestler, Hans;
- Chheda, Himanshu;
- Eisele, Lewin;
- Gustafsson, Stefan;
- Steinthorsdottir, Valgerdur;
- Thorleifsson, Gudmar;
- Qi, Lu;
- Karssen, Lennart C;
- van Leeuwen, Elisabeth M;
- Willems, Sara M;
- Li, Man;
- Chen, Han;
- Fuchsberger, Christian;
- Kwan, Phoenix;
- Ma, Clement;
- Linderman, Michael;
- Lu, Yingchang;
- Thomsen, Soren K;
- Rundle, Jana K;
- Beer, Nicola L;
- van de Bunt, Martijn;
- Chalisey, Anil;
- Kang, Hyun Min;
- Voight, Benjamin F;
- Abecasis, Gonçalo R;
- Almgren, Peter;
- Baldassarre, Damiano;
- Balkau, Beverley;
- Benediktsson, Rafn;
- Blüher, Matthias;
- Boeing, Heiner;
- Bonnycastle, Lori L;
- Bottinger, Erwin P;
- Burtt, Noël P;
- Carey, Jason;
- Charpentier, Guillaume;
- Chines, Peter S;
- Cornelis, Marilyn C;
- Couper, David J;
- Crenshaw, Andrew T;
- van Dam, Rob M;
- Doney, Alex SF;
- Dorkhan, Mozhgan;
- Edkins, Sarah;
- Eriksson, Johan G;
- Esko, Tonu;
- Eury, Elodie;
- Fadista, João;
- Flannick, Jason;
- Fontanillas, Pierre;
- Fox, Caroline;
- Franks, Paul W;
- Gertow, Karl;
- Gieger, Christian;
- Gigante, Bruna;
- Gottesman, Omri;
- Grant, George B;
- Grarup, Niels;
- Groves, Christopher J;
- Hassinen, Maija;
- Have, Christian T;
- Herder, Christian;
- Holmen, Oddgeir L;
- Hreidarsson, Astradur B;
- Humphries, Steve E;
- Hunter, David J;
- Jackson, Anne U;
- Jonsson, Anna;
- Jørgensen, Marit E;
- Jørgensen, Torben;
- Kao, Wen-Hong L;
- Kerrison, Nicola D;
- Kinnunen, Leena;
- Klopp, Norman;
- Kong, Augustine;
- Kovacs, Peter;
- Kraft, Peter;
- Kravic, Jasmina;
- Langford, Cordelia;
- Leander, Karin;
- Liang, Liming;
- Lichtner, Peter;
- Lindgren, Cecilia M;
- Lindholm, Eero;
- Linneberg, Allan;
- Liu, Ching-Ti;
- Lobbens, Stéphane;
- Luan, Jian'an;
- Lyssenko, Valeriya;
- Männistö, Satu;
- McLeod, Olga;
- Meyer, Julia;
- Mihailov, Evelin;
- Mirza, Ghazala;
- Mühleisen, Thomas W;
- Müller-Nurasyid, Martina;
- Navarro, Carmen;
- Nöthen, Markus M;
- Oskolkov, Nikolay N;
- Owen, Katharine R;
- Palli, Domenico;
- Pechlivanis, Sonali;
- Peltonen, Leena;
- Perry, John RB;
- Platou, Carl GP;
- Roden, Michael;
- Ruderfer, Douglas;
- Rybin, Denis;
- van der Schouw, Yvonne T;
- Sennblad, Bengt;
- Sigurðsson, Gunnar;
- Stančáková, Alena;
- Steinbach, Gerald;
- Storm, Petter;
- Strauch, Konstantin;
- Stringham, Heather M;
- Sun, Qi;
- Thorand, Barbara;
- Tikkanen, Emmi;
- Tonjes, Anke;
- Trakalo, Joseph;
- Tremoli, Elena;
- Tuomi, Tiinamaija;
- Wennauer, Roman;
- Wiltshire, Steven;
- Wood, Andrew R;
- Zeggini, Eleftheria;
- Dunham, Ian;
- Birney, Ewan;
- Pasquali, Lorenzo;
- Ferrer, Jorge;
- Loos, Ruth JF;
- Dupuis, Josée;
- Florez, Jose C;
- Boerwinkle, Eric;
- Pankow, James S;
- van Duijn, Cornelia;
- Sijbrands, Eric;
- Meigs, James B;
- Hu, Frank B;
- Thorsteinsdottir, Unnur;
- Stefansson, Kari;
- Lakka, Timo A;
- Rauramaa, Rainer;
- Stumvoll, Michael;
- Pedersen, Nancy L;
- Lind, Lars;
- Keinanen-Kiukaanniemi, Sirkka M;
- Korpi-Hyövälti, Eeva;
- Saaristo, Timo E;
- Saltevo, Juha;
- Kuusisto, Johanna;
- Laakso, Markku;
- Metspalu, Andres;
- Erbel, Raimund;
- Jöcke, Karl-Heinz;
- Moebus, Susanne;
- Ripatti, Samuli;
- Salomaa, Veikko;
- Ingelsson, Erik;
- Boehm, Bernhard O;
- Bergman, Richard N;
- Collins, Francis S;
- Mohlke, Karen L;
- Koistinen, Heikki;
- Tuomilehto, Jaakko;
- Hveem, Kristian;
- Njølstad, Inger;
- Deloukas, Panagiotis;
- Donnelly, Peter J;
- Frayling, Timothy M;
- Hattersley, Andrew T;
- de Faire, Ulf;
- Hamsten, Anders;
- Illig, Thomas;
- Peters, Annette;
- Cauchi, Stephane;
- Sladek, Rob;
- Froguel, Philippe;
- Hansen, Torben;
- Pedersen, Oluf;
- Morris, Andrew D;
- Palmer, Collin NA;
- Kathiresan, Sekar;
- Melander, Olle;
- Nilsson, Peter M;
- Groop, Leif C;
- Barroso, Inês;
- Langenberg, Claudia;
- Wareham, Nicholas J;
- O'Callaghan, Christopher A;
- Gloyn, Anna L;
- Altshuler, David;
- Boehnke, Michael;
- Teslovich, Tanya M;
- McCarthy, Mark I;
- Morris, Andrew P
Published Web Location
https://doi.org/10.1038/ng.3437Abstract
Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine mapping and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants is enriched for overlap with FOXA2 binding sites in human islet and liver cells, and they show that a likely causal variant near MTNR1B increases FOXA2-bound enhancer activity, providing a molecular mechanism to explain the effect of this locus on disease risk.
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