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Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
- Perera, Rushika M;
- Stoykova, Svetlana;
- Nicolay, Brandon N;
- Ross, Kenneth N;
- Fitamant, Julien;
- Boukhali, Myriam;
- Lengrand, Justine;
- Deshpande, Vikram;
- Selig, Martin K;
- Ferrone, Cristina R;
- Settleman, Jeff;
- Stephanopoulos, Gregory;
- Dyson, Nicholas J;
- Zoncu, Roberto;
- Ramaswamy, Sridhar;
- Haas, Wilhelm;
- Bardeesy, Nabeel
Published Web Location
https://doi.org/10.1038/nature14587Abstract
The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.
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