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Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination

  • Author(s): Li, Joachim
  • Finn, KJ
  • Li, JJ
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3536649?pdf=render
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Abstract

Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution, and drive the initiation and/or progression of various cancers. The mechanisms underlying these cop

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