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Characteristics at the time of oxygen initiation associated with its adherence: Findings from the COPD Long-term Oxygen Treatment Trial
- Moy, Marilyn L;
- Harrington, Kathleen F;
- Sternberg, Alice L;
- Krishnan, Jerry A;
- Albert, Richard K;
- Au, David H;
- Casaburi, Richard;
- Criner, Gerard J;
- Diaz, Philip;
- Kanner, Richard E;
- Panos, Ralph J;
- Stibolt, Thomas;
- Stoller, James K;
- Tonascia, James;
- Yusen, Roger D;
- Tan, Ai-Yui M;
- Fuhlbrigge, Anne L;
- Group, for the LOTT Research
Published Web Location
https://doi.org/10.1016/j.rmed.2019.02.004Abstract
Rationale
Characteristics associated with adherence to long-term oxygen therapy (LTOT) in COPD remain unclear.Objectives
To identify patient characteristics at the time of oxygen initiation associated with its adherence.Methods
We conducted a secondary analysis of data from 359 COPD participants assigned to oxygen in the Long-term Oxygen Treatment Trial. Participants were prescribed continuous (n = 214) or intermittent (n = 145) oxygen based on desaturation patterns at study entry. At the time of initial prescription, participants rated their perceived readiness, confidence, and importance to use oxygen on a 0-10 scale (0 = not at all, 10 = very much). During follow-up, they self-reported average hours per day of use (adherence). Adherence was averaged over short-term (0-30 days), medium-term (months 9-12), and long-term (month 13 to last follow-up) intervals. Multivariable logistic regression models explored characteristics associated with high adherence (≥16 h/day [continuous] or ≥8 h/day [intermittent]) during each time interval.Results
Participant readiness, confidence, and importance at the time of oxygen initiation were associated with high short- and medium-term adherence. For each unit increase in baseline readiness, the odds of high short-term adherence increased by 21% (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.05-1.40) and 94% (OR 1.94, 95% CI 1.45-2.59) in the continuous and intermittent groups, respectively. In both groups, high adherence in the medium-term was associated with high adherence in the long-term (continuous, OR 12.49, 95% CI 4.90-31.79; intermittent, OR 38.08, 95% CI 6.96-208.20).Conclusions
Readiness, confidence, and importance to use LTOT at initiation, and early high adherence, are significantly associated with long-term oxygen adherence.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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