Le, Hoan N; Tran, Vuvi G; Vu, Trang TT; Gras, Emmanuelle; Le, Vien TM; Pinheiro, Marcos Gabriel; Aguiar-Alves, Fábio; Schneider-Smith, Erika; Carter, Henry Clay; Sellman, Bret R; Stover, C Kendall; DiGiandomenico, Antonio; Diep, Binh An

doi:10.1128/aac.00710-19

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Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models

2019

Published Web Location

https://doi.org/10.1128/aac.00710-19

Abstract

Pseudomonas aeruginosa is a challenge for clinicians due to increasing drug resistance and dwindling treatment options. We report on the activity of MEDI3902, an antibody targeting type 3 secretion protein PcrV and Psl exopolysaccharide, in rabbit bloodstream and lung infection models. MEDI3902 prophylaxis or treatment was protective in both acute models and exhibited enhanced activity when combined with a subtherapeutic dose of meropenem. These findings further support MEDI3902 for the prevention or treatment of serious P. aeruginosa infections.

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Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models

Published Web Location