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CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

  • Author(s): Charo, Israel
  • Sennlaub, F
  • Auvynet, C
  • Calippe, B
  • Lavalette, S
  • Poupel, L
  • Hu, SJ
  • Dominguez, E
  • Camelo, S
  • Levy, O
  • Guyon, E
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3840491?pdf=render
No data is associated with this publication.
Abstract

Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increas

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