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SpectralTDF: transition densities of diffusion processes with time-varying selection parameters, mutation rates and effective population sizes
Published Web Location
https://doi.org/10.1093/bioinformatics/btv627Abstract
Motivation
In the Wright-Fisher diffusion, the transition density function describes the time evolution of the population-wide frequency of an allele. This function has several practical applications in population genetics and computing it for biologically realistic scenarios with selection and demography is an important problem.Results
We develop an efficient method for finding a spectral representation of the transition density function for a general model where the effective population size, selection coefficients and mutation parameters vary over time in a piecewise constant manner.Availability and implementation
The method, called SpectralTDF, is available at https://sourceforge.net/projects/spectraltdf/Contact
yss@berkeley.eduSupplementary information
Supplementary data are available at Bioinformatics online.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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