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Cortical Representation of a Myopic Peripapillary Crescent
Published Web Location
http://www.sciencedirect.com/science/article/pii/S0161642016300203No data is associated with this publication.
Abstract
Purpose
To determine how formation of an acquired myopic crescent adjacent to the optic disc affects metabolic activity in the primary visual cortex.Design
Laboratory animal study.Participants
Three macaque monkeys.Methods
The blind spot region in the primary visual cortex was labeled by cytochrome oxidase (CO) histochemistry analysis or [(3)H]proline autoradiography.Main outcome measures
Visualization of the representation of the blind spot and myopic peripapillary crescent in the visual cortex.Results
In high myopia, a region resembling the myopic peripapillary crescent was visible in cortical sections processed for CO. In this region, metabolic activity was reduced in ocular dominance columns that normally would be driven by input from retina corresponding to the myopic peripapillary crescent.Conclusions
The formation of a myopic crescent is accompanied by loss of metabolic activity in the cortex supplied by the affected retina. This observation confirms that retinal tissue is damaged by the development of a myopic crescent, rather than simply translocated in a temporal direction. The cortical defect matches the myopic peripapillary crescent in size and shape, indicating that fill-in of the retinotopic map by healthy, surrounding retina does not occur.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.