Skip to main content
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Blood-brain barrier: selective changes during maturation.


The penetration of substances relative to freely-diffusible antipyrine was determined in regions of the maturing chick brain. Two amino acids were studied: tyrosine, which is essential to the brain and is a neurotransmitter precursor, and proline, a non-essential amino acid. During maturation the barrier toward proline developed to a much greater extent than that toward tyrosine. The penetrance of d-glucose, the main energy source for the brain, increased during maturation, while the penetrance of l-glucose, a metabolically inert stereoisomer of d-glucose, decreased. The results suggest differing rates of development of the blood-brain barrier to various substances. © 1976.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View