- Main
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
- Cerhan, James R;
- Berndt, Sonja I;
- Vijai, Joseph;
- Ghesquières, Hervé;
- McKay, James;
- Wang, Sophia S;
- Wang, Zhaoming;
- Yeager, Meredith;
- Conde, Lucia;
- de Bakker, Paul IW;
- Nieters, Alexandra;
- Cox, David;
- Burdett, Laurie;
- Monnereau, Alain;
- Flowers, Christopher R;
- De Roos, Anneclaire J;
- Brooks-Wilson, Angela R;
- Lan, Qing;
- Severi, Gianluca;
- Melbye, Mads;
- Gu, Jian;
- Jackson, Rebecca D;
- Kane, Eleanor;
- Teras, Lauren R;
- Purdue, Mark P;
- Vajdic, Claire M;
- Spinelli, John J;
- Giles, Graham G;
- Albanes, Demetrius;
- Kelly, Rachel S;
- Zucca, Mariagrazia;
- Bertrand, Kimberly A;
- Zeleniuch-Jacquotte, Anne;
- Lawrence, Charles;
- Hutchinson, Amy;
- Zhi, Degui;
- Habermann, Thomas M;
- Link, Brian K;
- Novak, Anne J;
- Dogan, Ahmet;
- Asmann, Yan W;
- Liebow, Mark;
- Thompson, Carrie A;
- Ansell, Stephen M;
- Witzig, Thomas E;
- Weiner, George J;
- Veron, Amelie S;
- Zelenika, Diana;
- Tilly, Hervé;
- Haioun, Corinne;
- Molina, Thierry Jo;
- Hjalgrim, Henrik;
- Glimelius, Bengt;
- Adami, Hans-Olov;
- Bracci, Paige M;
- Riby, Jacques;
- Smith, Martyn T;
- Holly, Elizabeth A;
- Cozen, Wendy;
- Hartge, Patricia;
- Morton, Lindsay M;
- Severson, Richard K;
- Tinker, Lesley F;
- North, Kari E;
- Becker, Nikolaus;
- Benavente, Yolanda;
- Boffetta, Paolo;
- Brennan, Paul;
- Foretova, Lenka;
- Maynadie, Marc;
- Staines, Anthony;
- Lightfoot, Tracy;
- Crouch, Simon;
- Smith, Alex;
- Roman, Eve;
- Diver, W Ryan;
- Offit, Kenneth;
- Zelenetz, Andrew;
- Klein, Robert J;
- Villano, Danylo J;
- Zheng, Tongzhang;
- Zhang, Yawei;
- Holford, Theodore R;
- Kricker, Anne;
- Turner, Jenny;
- Southey, Melissa C;
- Clavel, Jacqueline;
- Virtamo, Jarmo;
- Weinstein, Stephanie;
- Riboli, Elio;
- Vineis, Paolo;
- Kaaks, Rudolph;
- Trichopoulos, Dimitrios;
- Vermeulen, Roel CH;
- Boeing, Heiner;
- Tjonneland, Anne;
- Angelucci, Emanuele;
- Di Lollo, Simonetta;
- Rais, Marco;
- Birmann, Brenda M;
- Laden, Francine;
- Giovannucci, Edward;
- Kraft, Peter;
- Huang, Jinyan;
- Ma, Baoshan;
- Ye, Yuanqing;
- Chiu, Brian CH;
- Sampson, Joshua;
- Liang, Liming;
- Park, Ju-Hyun;
- Chung, Charles C;
- Weisenburger, Dennis D;
- Chatterjee, Nilanjan;
- Fraumeni, Joseph F;
- Slager, Susan L;
- Wu, Xifeng;
- de Sanjose, Silvia;
- Smedby, Karin E;
- Salles, Gilles;
- Skibola, Christine F;
- Rothman, Nathaniel;
- Chanock, Stephen J
- et al.
Published Web Location
https://doi.org/10.1038/ng.3105Abstract
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-