Skip to main content
eScholarship
Open Access Publications from the University of California

Associations of insulin resistance with cognition in individuals without diagnosed diabetes: Results from the Hispanic Community Health Study/Study of Latinos.

  • Author(s): Gonzales, Mitzi M
  • Durazo-Arvizu, Ramon A
  • Sachdeva, Shruti
  • Unterman, Terry G
  • O'Brien, Matthew J
  • Gallo, Linda C
  • Talavera, Gregory A
  • Kaplan, Robert C
  • Cai, Jianwen
  • Schneiderman, Neil
  • Espinoza Giacinto, Rebeca A
  • González, Hector M
  • Daviglus, Martha L
  • Lamar, Melissa
  • et al.

Published Web Location

https://www.sciencedirect.com/science/article/pii/S0168822718314918?via%3Dihub
No data is associated with this publication.
Abstract

AIMS:Insulin resistance (IR) adversely impacts memory and executive functioning in non-Hispanic whites without diabetes. Less is known in Hispanics/Latinos, despite the fact that Hispanics/Latinos have higher rates of insulin resistance than non-Hispanic whites. We investigated the association between IR and cognition and its variation by age. METHODS:Data from 5,987 participants 45-74 years old without diabetes from the Hispanic Community Health Study/Study of Latinos. IR was considered continuously using homeostasis model assessment for insulin resistance (HOMA-IR) and also dichotomized based on clinically relevant thresholds for hyperinsulinemia (fasting insulin>84.73pmol/L or HOMA-IR>2.6) and sample-based norms (75th percentile of fasting insulin or HOMA-IR). Cognitive testing included the Brief Spanish English Verbal Learning Test (B-SEVLT), Verbal Fluency, and Digit Symbol Substitution. RESULTS:There was 90% overlap in participant categorization comparing clinically relevant and sample-based thresholds. In separate fully-adjusted linear regression models, age modified the association between HOMA-IR and Digit Symbol Substitution (p=0.02); advancing age combined with higher HOMA-IR levels resulted in higher scores. Age also modified the association between clinically relevant hyperinsulinemia and B-SEVLT recall (p=0.03); with increasing age came worse performance for individuals with hyperinsulinemia. CONCLUSION:The relationship of IR with cognition in Hispanics/Latinos without diabetes may reflect an age- and test-dependent state.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item