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Immunological memory to SARS-CoV-2 assessed for up to eight months after infection.

  • Author(s): Dan, Jennifer M;
  • Mateus, Jose;
  • Kato, Yu;
  • Hastie, Kathryn M;
  • Yu, Esther Dawen;
  • Faliti, Caterina E;
  • Grifoni, Alba;
  • Ramirez, Sydney I;
  • Haupt, Sonya;
  • Frazier, April;
  • Nakao, Catherine;
  • Rayaprolu, Vamseedhar;
  • Rawlings, Stephen A;
  • Peters, Bjoern;
  • Krammer, Florian;
  • Simon, Viviana;
  • Saphire, Erica Ollmann;
  • Smith, Davey M;
  • Weiskopf, Daniela;
  • Sette, Alessandro;
  • Crotty, Shane
  • et al.
Abstract

Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4 + T cells and CD8 + T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4 + T cell, and CD8 + T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

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