Unraveling the mechanism of cell death induced by chemical fibrils
- Author(s): Wells, James;
- Weissman, Jonathan;
- Kampmann, Martin
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4201873?pdf=render
© 2014 Nature America, Inc. All rights reserved.We previously discovered a small-molecule inducer of cell death, named 1541, that noncovalently self-assembles into chemical fibrils ('chemi-fibrils') and activates procaspase-3 in vitro. We report here that