Anaplastic Thyroid Carcinoma Histologically Mimicking a Plasmacytoma.
- Author(s): Mo, Joshua H;
- Tan, Donald;
- Zhao, Xiaohui S;
- Tjoa, Tjoson;
- Wang, Beverly Y
- et al.
Published Web Locationhttps://doi.org/10.3390/diagnostics10010029
Anaplastic (undifferentiated) thyroid carcinoma (ATC) is a rare malignancy which may arise from transformation of a pre-existing differentiated carcinoma. We report the unique case where a lesion of thyroid origin presented with the histological features of mature plasma cells. Immunohistochemistry confirmed the lesion to be an anaplastic thyroid carcinoma arising from papillary thyroid carcinoma. A tumor mimicking a malignancy of a different cellular origin can lead clinicians to incorrect treatment approaches. Careful correlation with clinical details and knowledge of these unique presentations is important for reaching the correct diagnosis.