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Anaplastic Thyroid Carcinoma Histologically Mimicking a Plasmacytoma.

  • Author(s): Mo, Joshua H
  • Tan, Donald
  • Zhao, Xiaohui S
  • Tjoa, Tjoson
  • Wang, Beverly Y
  • et al.

Anaplastic (undifferentiated) thyroid carcinoma (ATC) is a rare malignancy which may arise from transformation of a pre-existing differentiated carcinoma. We report the unique case where a lesion of thyroid origin presented with the histological features of mature plasma cells. Immunohistochemistry confirmed the lesion to be an anaplastic thyroid carcinoma arising from papillary thyroid carcinoma. A tumor mimicking a malignancy of a different cellular origin can lead clinicians to incorrect treatment approaches. Careful correlation with clinical details and knowledge of these unique presentations is important for reaching the correct diagnosis.

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