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Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications
- LeValley, Paige J;
- Ovadia, Elisa M;
- Bresette, Christopher A;
- Sawicki, Lisa A;
- Maverakis, Emanual;
- Bai, Shi;
- Kloxin, April M
Published Web Location
https://doi.org/10.1039/c8cc03218aAbstract
An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.
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