Viral hijacking of cellular metabolism.
- Author(s): Thaker, Shivani K
- Ch'ng, James
- Christofk, Heather R
- et al.
Published Web Locationhttps://doi.org/10.1186/s12915-019-0678-9
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to identify critical metabolic nodes for cancer anabolism. We also discuss the need for more mechanistic studies identifying viral proteins responsible for metabolic hijacking and for in vivo studies of viral-induced metabolic rewiring. Improved technologies for detailed metabolic measurements and genetic manipulation will lead to important discoveries over the next decade.