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A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

  • Author(s): Minor, Daniel
  • Renslo, Adam
  • Arkin, Michelle
  • Bagriantsev, SN
  • Ang, KH
  • Gallardo-Godoy, A
  • Clark, KA
  • Arkin, MR
  • Renslo, AR
  • Minor, DL
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3747594?pdf=render
No data is associated with this publication.
Abstract

K2P (KCNK) potassium channels generate "leak" potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiological importance, K2Ps lack specific pharmacology. Addressin

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