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Fractionation of a herbal antidiarrheal medicine reveals Eugenol as an inhibitor of Ca2+-activated Cl- channel TMEM16A

  • Author(s): Verkman, Alan
  • Yao, Z
  • Namkung, W
  • Ko, EA
  • Park, J
  • Tradtrantip, L
  • Verkman, AS
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3364195?pdf=render
No data is associated with this publication.
Abstract

The Ca2+-activated Cl- channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl- conductance. C18-reversed-phase HPLC fr

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