Fractionation of a herbal antidiarrheal medicine reveals Eugenol as an inhibitor of Ca2+-activated Cl- channel TMEM16A
- Author(s): Verkman, Alan
- Yao, Z
- Namkung, W
- Ko, EA
- Park, J
- Tradtrantip, L
- Verkman, AS
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3364195?pdf=render
The Ca2+-activated Cl- channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl- conductance. C18-reversed-phase HPLC fr
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