Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling.
- Author(s): Rajagopalan, Sheila S
- Miller, Andrew M
- de Hemptinne, Coralie
- San Luciano, Marta
- Ostrem, Jill L
- Starr, Philip A
- et al.
Published Web Locationhttps://doi.org/10.1016/j.parkreldis.2019.08.018
Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude. Here we show by noninvasive scalp electroencephalography that withdrawal of chronic DBS elevates phase-amplitude coupling, in proportion to the worsening of contralateral rigidity.