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Luminal cells GATA have it

Published Web Location

https://doi.org/10.1038/ncb0207-135
Abstract

The transcription factor GATA-3 is necessary for the formation of a mammary gland and the maintenance of mammary-cell differentiation. The loss of GATA-3 function in a fully formed mammary gland generates oestrogen receptor-negative, proliferating cells that lack expression of myoepithelial markers. Cells with similar characteristics in breast cancer are associated with poor prognosis.

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