IL-2: Change Structure … Change Function.
- Author(s): Bluestone, Jeffrey A;
- Crellin, Natasha;
- Trotta, Eleonora
- et al.
Published Web Locationhttps://doi.org/10.1016/j.immuni.2015.05.002
In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.