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IL-2: Change Structure … Change Function.

  • Author(s): Bluestone, Jeffrey A;
  • Crellin, Natasha;
  • Trotta, Eleonora
  • et al.
Abstract

In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.

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