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Acute Alcohol Exposure Shifts Metabolism of Breast Cancer Cells

  • Author(s): LE, IVY THUY VY
  • Advisor(s): Digman, Michelle
  • et al.
Abstract

Alcohol consumption has been recognized as a risk factor for breast cancer. It is positively correlated with the progression of breast cancer. Ethanol is studied to shift the metabolism of breast cancer cells. According to the Warburg Effect, cancer cells predominantly produce their energy through a high rate of glycolysis. I hypothesized that with acute ethanol exposure the breast cancer cells will shift their metabolism from oxidative phosphorylation to glycolysis. The metabolic shift of cancer cells changes the ratio of free and protein bound NADH, which is an essential coenzyme in cellular metabolic pathway. As such, investigating the fluorescent lifetime of free and protein bound NADH of breast cancer cells through Fluorescence Lifetime Imaging Microscopy (FLIM), I report the preliminary results on the metabolic shifts of two breast cancer cell lines: MDA-MB-231 and MCF-7 due to acute alcohol exposure.

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