Liang, Geoffrey; Zhu, Feng; Mirza, Ali I; Bar-Or, Amit; Bernstein, Charles N; Bonner, Christine; Forbes, Jessica D; Graham, Morag; Hart, Janace; Knox, Natalie C; Marrie, Ruth Ann; O’Mahony, Julia; Van Domselaar, Gary; Yeh, E Ann; Zhao, Yinshan; Banwell, Brenda; Waubant, Emmanuelle; Tremlett, Helen; Network, the Canadian Paediatric Demyelinating Disease

doi:10.1177/13524585221079533

Download PDF

Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases

Published Web Location

https://doi.org/10.1177/13524585221079533

Abstract

Objective

Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS).

Methods

A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed.

Results

Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus - Solobacterium did (p = 0.001).

Conclusions

The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content

For improved accessibility of PDF content, download the file to your device.

UCSF