UC Irvine

Mechanical forces are generated during tumor growth and progression. Numerous studies have investigated the effect of mechanical stress on cell behaviors, but there is still much to be understood. Many experimental and theoretical studies have investigatedthe effect of mechanical forces using multicellular tumor spheroids (MCTSs) as models of pre-vascular tumor growth. Here, we review two theoretical studies. In the first, “Influence of the mechanical properties of the necrotic core on the growth and remodeling of tumour spheroids,” Giverso and Preziosi (2019) [1] develop a mathematical model to study the growth and remodeling of a MCTSwith a necrotic core, which is composed of either calcified debris or a liquid cavity. In the second, “An avascular tumor growth model based on porous media mechanics and evolving natural states,” Mascheroniet al. (2018) [2] analyze the influence of the microenvironment on tumor growth and remodeling.