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FlyRNAi: the Drosophila RNAi screening center database.

  • Author(s): Flockhart, Ian;
  • Booker, Matthew;
  • Kiger, Amy;
  • Boutros, Michael;
  • Armknecht, Susan;
  • Ramadan, Nadire;
  • Richardson, Kris;
  • Xu, Andrew;
  • Perrimon, Norbert;
  • Mathey-Prevot, Bernard
  • et al.

RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database ( in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.

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