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Saccharomonopyrones A-C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490.

  • Author(s): Yim, Chae-Yoon
  • Le, Tu Cam
  • Lee, Tae Gu
  • Yang, Inho
  • Choi, Hansol
  • Lee, Jusung
  • Kang, Kyung-Yun
  • Lee, Jin Sil
  • Lim, Kyung-Min
  • Yee, Sung-Tae
  • Kang, Heonjoong
  • Nam, Sang-Jip
  • Fenical, William
  • et al.
Abstract

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 μM.

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