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Widespread adenine N6-methylation of active genes in fungi
- Mondo, Stephen J;
- Dannebaum, Richard O;
- Kuo, Rita C;
- Louie, Katherine B;
- Bewick, Adam J;
- LaButti, Kurt;
- Haridas, Sajeet;
- Kuo, Alan;
- Salamov, Asaf;
- Ahrendt, Steven R;
- Lau, Rebecca;
- Bowen, Benjamin P;
- Lipzen, Anna;
- Sullivan, William;
- Andreopoulos, Bill B;
- Clum, Alicia;
- Lindquist, Erika;
- Daum, Christopher;
- Northen, Trent R;
- Kunde-Ramamoorthy, Govindarajan;
- Schmitz, Robert J;
- Gryganskyi, Andrii;
- Culley, David;
- Magnuson, Jon;
- James, Timothy Y;
- O'Malley, Michelle A;
- Stajich, Jason E;
- Spatafora, Joseph W;
- Visel, Axel;
- Grigoriev, Igor V
Published Web Location
https://www.nature.com/articles/ng.3859#acknowledgementsAbstract
Igor Grigoriev and colleagues perform single-molecule real-time sequencing on 16 diverse fungal species to evaluate levels of adenine methylation (6mA). They find that almost 3% of all adenines are methylated in early-diverging fungi, and they identify clusters of methylated adenines that are enriched at transcription start sites of active genes.
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