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Open Access Publications from the University of California

Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: Results from the retained organic solutes and clinical outcomes (ROSCO) investigators

  • Author(s): Powe, Neil
  • Melamed, ML
  • Plantinga, L
  • Shafi, T
  • Parekh, R
  • Meyer, TW
  • Hostetter, TH
  • Coresh, J
  • Powe, NR
  • et al.

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Background: Multiple solutes are retained in uremia, but it is currently unclear which solutes are toxic. Small studies suggest that protein-bound solutes, such as p-cresol sulfate and indoxyl sulfate and intracellular solutes, such as methylamine (MMA) an

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