Skip to main content
Open Access Publications from the University of California

UC San Diego

UC San Diego Electronic Theses and Dissertations bannerUC San Diego

The calcification of staphylococcus aureus bacteria by the mineralization by inhibitor exclusion mechanism : a potential defense mechanism against bacterial infections

  • Author(s): Truong, Linh Y.
  • et al.

The emergence of antibiotic resistant bacteria has become a worldwide concern. Our goal was to develop a new strategy to treat antibiotic resistant bacterial infections. We investigated whether bacteria are killed by the Mineralization by Inhibitor Exclusion (MIE) mechanism. This mechanism exploits the size exclusion characteristics of the bacterial cell wall, and therefore has no impact on mammalian cells. Our studies demonstrate that live Staphylococcus aureus are calcified by the MIE mechanism, and that calcification kills bacteria. The MIE procedure kills bacteria within hours at room temperature and physiological pH, and requires only calcium, phosphate, and a macromolecular calcification inhibitor

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View