Akt-dependent phosphorylation of hepatic Foxo1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity
- Author(s): Farese, Robert
- Sajan, MP
- Acevedo-Duncan, ME
- Standaert, ML
- Ivey, RA
- Lee, M
- Farese, RV
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4113067?pdf=render
Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in diet-induced obesity (DIO) are obscure. Here, we examined insulin signaling to Akt and atypical protein kinase C (aPKC) in liver and muscle and hepatic enzyme expression
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