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Akt-dependent phosphorylation of hepatic Foxo1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity

  • Author(s): Farese, Robert
  • Sajan, MP
  • Acevedo-Duncan, ME
  • Standaert, ML
  • Ivey, RA
  • Lee, M
  • Farese, RV
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4113067?pdf=render
No data is associated with this publication.
Abstract

Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in diet-induced obesity (DIO) are obscure. Here, we examined insulin signaling to Akt and atypical protein kinase C (aPKC) in liver and muscle and hepatic enzyme expression

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