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FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues

  • Author(s): Portale, Anthony
  • Miller, Walter
  • Chanakul, A
  • Zhang, MYH
  • Louw, A
  • Armbrecht, HJ
  • Miller, WL
  • Portale, AA
  • Perwad, F
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3760837?pdf=render
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Abstract

The mitochondrial enzyme 25-hydroxyvitamin D 1α-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). Renal 1α-hydroxylase activity is the principal determinant o

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