Skip to main content
Download PDF
- Main
Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.
- Author(s): Wen, Yan-Zi
- Zheng, Ling-Ling
- Liao, Jian-You
- Wang, Ming-Hui
- Wei, Ying
- Guo, Xue-Min
- Qu, Liang-Hu
- Ayala, Francisco J
- Lun, Zhao-Rong
- et al.
Abstract
Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.