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Open Access Publications from the University of California

Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei

  • Author(s): Wen, YZ
  • Zheng, LL
  • Liao, JY
  • Wang, MH
  • Wei, Y
  • Guo, XM
  • Qu, LH
  • Ayala, FJ
  • Lun, ZR
  • et al.

Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.

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