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Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.

  • Author(s): Wen, Yan-Zi
  • Zheng, Ling-Ling
  • Liao, Jian-You
  • Wang, Ming-Hui
  • Wei, Ying
  • Guo, Xue-Min
  • Qu, Liang-Hu
  • Ayala, Francisco J
  • Lun, Zhao-Rong
  • et al.
Abstract

Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.

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